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Ryota Matsumoto is the renowned philosopher and visual artist known for the hybrid art and postdigital theory. He is a principal and founder of an award-winning interdisciplinary design office, Ryota Matsumoto Studio based in New York and Tokyo. Education Born in Tokyo, he was raised in Hong Kong and Japan. He received a Master of Architecture degree from University of Pennsylvania in 2007 after his studies at Architectural Association in London, Mackintosh School of Architecture, Glasgow School of Art and University of Miami in early 90’s. Matsumoto has previously collaborated with a cofounder of the Metabolist Movement, Kisho Kurokawa, and with Arata Isozaki, Peter Christopherson, Cesar Pelli and MIT Media Lab before establishing his office. Architectural and Visual Work As a designer and consultant of Nihon Seikei Inc. and Japanese railway, he has worked on high-profile projects including Kyushu University Ito Campus masterplan(2003-2005), Shinjuku redevelopment project in Tokyo(2009-2012), Bach Mai hospital in Hanoi(2000) and Qingdao mixed-use development in China(2011). He has presented his work on posthumanism, digital design and bio art at the 5th symposium of the Imaginaries of the Future at Cornell University, the Espaciocenter workshop at TEA Tenerife Espacio de las Artes, Oslo National Academy of the Arts, UCI Claire Trevor School of the Arts and NTT InterCommunication Center as a visual artist. As a video producer, he has worked with Peter Christopherson for Japanese Nike commercial and contributed to the promotional projects for his first solo album as Threshold Houseboys Choir. His academic career started as a teaching assistant for architectural historian, Vincent Joseph Scully Jr. and his seminar, the Natural and Manmade in 1993. During his visiting fellowship at the Glasgow school of Art, he has been engaged in research on the process of integrated urban regeneration under the guidance of Giancarlo De Carlo and Isi Metzstein. He continued his pursuit in urban studies and participated in seminal research projects with MIT Media Lab and KieranTimberlake exploring high-rise modular housing, sustainability and design interventions for Dhaka, Bangladesh in 2005. He has served as an MFA advisor of Transart institute, University of Plymouth and teaches at Asagaya Institute of Art and Design as a professor of practice. He is a research associate at the New Centre of Research Practice found by Mohammad Salemy, Jason Adams and Reza Negarestani. Matsumoto is the recipient of Visual Art Open First Prize, FILE (Electronic Language International Festival) Prix Lux Prize, Florence Biennale Mixed Media 2nd Place Award, Premio Ora Prize Italy 5th Edition, Premio Ora Prize Spain 1st Edition, Donkey Art Prize III Edition Finalist, Best of Show IGOA Toronto, Art Kudos Best of Show Award, Lynx International Prize Be Art Builder Award, Lumen Prize Finalist and Western Bureau Art Prize Honorable Mention. He was awarded the Gold Artist Prize from ArtAscent Journal, the 1st Place Prize from Exhibeo Art Magazine and the Award of Excellence from the Creative Quarterly Journal of Art and Design in 2015 and 2016. His work is part of the permanent collection of University of Texas at Tyler. His work, writings, and interviews were published in Kalubrt Magazine, University of North Carolina Wilmington Journal Palaver, Furtherfield.org, The Journal of Wild Culture, Studio Visit Magazine, Fresh Paint Magazine, H+ Magazine, International Artist Magazine, Made In Mind Magazine, Arizona State University Journal Superstition Review, Creative Review, Next Nature Network, Rhizome.org, Carbon Culture Review, KooZA/rch, Supersonic Art, Component Design (Winka Dubbeldam ed.), Post Digital Aethetics (Berry and Dieter ed.), Drawing Discourse (University of North Carolina Asheville), Highlike(SEPI-SP editors) and Drawing Futures (The Bartlett UCL) among others. Matsumoto s multidisciplinary projects have been exhibited recently at Meadows Gallery University of Texas at Tyler, S. Tucker Cooke Gallery University of North Carolina Asheville, Sebastopol Center for the Arts, National Museum of Korea, Van Der Plas Gallery, ArtHelix Gallery, Caelum Gallery, Limner Gallery, the Cello Factory, University of the District of Columbia, Lux Art Gallery, Studio Montclair, Manifest Gallery, Tenerife Espacio de las Artes, Art Basel Miami, ISEA International, FILE Sao Paulo, Nook Gllery and Arts and Heritage Centre Altrincham. He also had solo exhibitions at Transylvania University (2015), Los Angeles Center of Digital Art (2016) and Alviani ArtSpace, Pescara (2017). Official Website http //ryotamatsumoto.com
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telnetでブラウズ(HTTP) このページでは、インターネットでホームページなどをブラウジングするときに利用するHTTPプロトコルについて説明しています。 概要 HTTPプロトコルとは、Hypertext Transfer Protocolの略で、インターネットでホームページなどをブラウジングするときに利用しているプロトコルです。 HTTPプロトコルは、TCP/IP上のプロトコルで、通常80番ポートを使ってアクセスします。 詳細な定義は、以下のRFCで定義されています。 RFC-1945 HTTP/1.0 RFC-2068 HTTP/1.1 基本的に、メッセージを要求(リクエスト)し、その応答結果(レスポンス)を表示するだけです。 HTTPのアクセスログ ApacheなどのWebサーバのログを見ると、リクエストとレスポンスが、以下の形式で出力されます。 アクセスログの書式 アクセス元 - - [アクセス時間] メソッド名 URL名 プロトコルバージョン レスポンスコード 例: 10.0.1.20 - - [01/Jul/1999 23 22 46 +0900] GET /usr/joe/index.html HTTP/1.0 200 2060 メソッドの種類には、GETやPOSTなどがあります。 GETメソッドは、HTMLデータや画像データなどを取得する場合に使用します。 GETメソッドで要求すると、ヘッダ情報とHTMLデータが返却されます。 GETメソッドでCGIを呼び出すこともできます。 パラメータを渡す場合は、URLの後に ?name1=データ1 name2=データ2 という形式で指定します。 HEADメソッドは、ファイルサイズや更新日時を調べる場合に利用します。 HEADメソッドを利用すると、ヘッダ情報だけが返却されます。 POSTメソッドは、CGIなどにデータを渡す場合に使用します。 パラメータなどのデータは、環境変数などによって、CGIに渡ります。 以下に、HTTPのバージョンとメソッドの種類を示します。 メソッドの種類 HTTP/1.0 GET, HEAD, PUT, POST, DELETE, LINK, UNLINK HTTP/1.1 OPTIONS, TRACE, PATCH 以下に、レスポンスコードの一覧を示します。 100番台は通信エラー、200番台は正常終了、300番台はリダイレクト、400番台はクライアントエラー、500番台はサーバエラーを表しています。 リダイレクトとは、クライアントの指定したURLに移動した場合などに返却されます。 レスポンスコード コード 内容 コード 内容 100 Continue 101 Switching Protocols 200 OK 201 Created 202 Accepted 203 Non-Authoritative Information 204 No Content 205 Reset Content 206 Partial Content 300 Multiple Choices 301 Moved Permanently 302 Moved Temporarily 303 See Other 304 Not Modified 305 Use Proxy 400 Bad Request 401 Unauthorized 402 Payment Required 403 Forbidden 404 Not Found 405 Method Not Allowed 406 Not Acceptable 407 Proxy Authentication Required 408 Request Time-out 409 Conflict 410 Gone 411 Length Required 412 Precondition Failed 413 Request Entity Too Large 414 Request-URI Too Large 415 Unsupported Media Type 500 Internal Server Error 501 Not Implemented 502 Bad Gateway 503 Service Unavailable 504 Gateway Time-out 505 HTTP Version not supported レスポンスコードは、ログファイルなどに出力されますので、知っていると役に立つと思います。 telnetでブラウジング では、実際にtelnetでブラウジングしてみましょう。 telnetコマンドで、WWWサーバ名と、80番ポートを指定します。 Linux# telnet ash.jp 80 そこで、環境変数をすべて表示するCGI(env.cgi)を起動してみます。 まず、GETコマンドで、取得したいURLと、HTTPのバージョンを指定します。 GET /~joe/prog/cgi/env01.cgi HTTP/1.0 ここで、リターンのみを入力しても表示されますが、以下のオプションも入力してみます。 指定したオプションは、環境変数としてCGIに渡ります。 User-Agent Telnet [ja] (Linux) Host www.ash.jp リターンのみを入力すると、レスポンスと、HTMLが表示されます。 当然、HTMLのソースが表示されるだけですから、頭の中でHTMLを解析し画面イメージを想像する必要があります。 以下に実行結果を示します。 Linux# telnet ash.jp 80 Trying 210.154.87.18... Connected to ash.jp. Escape character is ^] . GET /~joe/prog/cgi/env01.cgi HTTP/1.0 User-Agent Telnet [ja] (Linux) Host ash.jp HTTP/1.1 200 OK DeleGate-Ver 5.8.8 (delay=7) Date Fri, 02 Jul 1999 09 56 24 GMT Server Apache/1.3.3 (Unix) Content-Type text/html Via 1.0 210.154.87.18 80 (DeleGate/5.8.8) Content-Length 954 html body h1 CGIでの環境変数一覧 /h1 hr h3 環境変数の表示 /h3 DOCUMENT_ROOT = /usr/local/share/apache/htm br GATEWAY_INTERFACE = CGI/1.1 br HTTP_FORWARDED = by http //210.154.87.18 80/ (DeleGate/5.8.8) for sv01.lo.ash.or .jp br HTTP_HOST = ash.jp br HTTP_USER_AGENT = Telnet [ja] (Linux) br HTTP_VIA = 1.0 210.154.87.18 80 (DeleGate/5.8.8) br PATH = /usr/local/sbin /usr/local/bin /sbin /usr/sbin /bin /usr/bin br QUERY_STRING = br REMOTE_ADDR = 10.0.1.254 br REMOTE_PORT = 12621 br REQUEST_METHOD = GET br REQUEST_URI = /~joe/prog/cgi/env01.cgi br SCRIPT_FILENAME = /home/joe/public_html/prog/cgi/env01.cgi br SCRIPT_NAME = /~joe/prog/cgi/env01.cgi br SERVER_ADMIN = info@ash.jp br SERVER_NAME = ash.jp br SERVER_PORT = 80 br SERVER_PROTOCOL = HTTP/1.0 br SERVER_SIGNATURE = ADDRESS Apache/1.3.3 Server at ash.jp Port 80 /ADDRESS br SERVER_SOFTWARE = Apache/1.3.3 (Unix) br hr br このCGIのソース: a href=env01.txt env01.cgi /a br /body /html Connection closed by foreign host. 最初の、HTTP/1.1 200 OKは、HTTPプロトコルで、正常に転送したことを表します。 その後にヘッダ情報が転送され、最後にHTMLのソースが転送されます。 環境変数として、以下の値が追加設定されているのが確認できます。 HTTP_HOST = ash.jp HTTP_USER_AGENT = Telnet [ja] (Linux) このように、HTTPプロトコルは、要求(リクエスト)に対して、応答(レスポンス)が返却されるだけのシンプルなプロトコルです。 余談ですが、HTTPプロトコルという呼び方は、Hyper Text Transfer Protocol プロトコルになって、プロトコルが2重になってしまい、おかしいです。 でも、この方がわかりやすいので、私はよく使います。
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ネットワークに戻る RFC2616概要 HTTP/1.1 RFC6265概要 HTTP状態管理機構 パーセントエンコーディング(URLエンコード) URLで意味を持つコードと混同する日本語などのバイナリや特殊記号を16進形式にして、先頭に%を付加した文字に変換する。正確に言うと、非予約文字、予約文字以外を変換する。 項目 説明 非予約文字 ASCIIのコード範囲内の英字(大文字・小文字)、数字、ハイフン “-”、ピリオド “.”、アンダースコア “_”、チルダ “~” 予約文字 URIを表す符号。ASCIIのコード範囲内のコロン “ ”、スラッシュ “/”、疑問符 “?”、シャープ “#”、角括弧 “[”、“]”、単価記号 “@”、感嘆符 “!”、ドル記号・ペソ記号 “$”、アンパサンド “ ”、アポストロフィー・シングルクオート “ ”、丸括弧 “(”、“)”、アスタリスク “*”、正符号・加算記号 “+”、コンマ “,”、セミコロン “;”、等号 “=” name=%E8%8F%85%E7%9B%B4%E4%BA%BA UTF-8で、%E8%8F%85:菅, %E7%9B%B4 直, %E4%BA%BA 人 x-www-form-urlencoded(URLエンコード) POSTのフォームデータをエンコードする。%を付加する方式は、パーセントエンコーディングと同じ。パーセントエンコーディングの予約文字も変換している スペースは"+"に変換。Javaのソースを見ると、英数字、"-","_", ".","*"以外を変換する BASE64 Wikipediaより データを64種類の印字可能な英数字のみを用いて、それ以外の文字を扱うことの出来ない通信環境にてマルチバイト文字やバイナリデータを扱うためのエンコード方式 7ビットのデータしか扱うことの出来ない電子メールにて広く利用されている A–Z, a–z, 0–9 までの62文字と、記号2つ (+ , /) 、さらにパディング(余った部分を詰める)のための記号として = が用いられる 76文字ごとに改行コードが入る Cookie Wikipediaより クッキーを設定する際、どの要求に対してクッキー情報を送り返すのか、URLの範囲を指定する。 規定値は、クッキーを設定したサーバに対するすべての要求であり、対象を広げることも狭めることもできる。ただし広げる場合でも、トップレベルドメインより狭い範囲でなければならない。 またクッキーの有効期限は、通常はブラウザを終了するまでだが、指定した期限まではブラウザを再度起動しても保持されるように設定することができる。有効期限の情報も、サーバからブラウザにクッキー情報を送信する段階で付加される。 無期限という設定は出来ない。 詳細: http //www.studyinghttp.net/cookies リクエスト 全てテキスト。行(CRLF)で区切られる。 フォーマット リクエストラインは1行。ヘッダは複数行。 大項目 小項目 説明 リクエストライン メソッド GET,POST,PUTなどのどれか。 リクエストURL リクエストを処理するURI プロトコルバージョン HTTPのバージョン。【例】HTTP/1.1 ヘッダ HOST リクエスト先のホスト名。必須項目 空行 POSTのときにヘッダの終了を示すために挿入される メッセージボディ POSTのときにリクエストデータを出力する 【例】 GET http //example.jp/31/31-001.php HTTP/1.1 リクエストライン Host example.jp --+ User-Agent Mozilla/5.0 (Windows NT 5.1; rv 2.0.1) Gecko/20100101 Firefox/4.0.1 | Accept text/html,application/xhtml+xml,application/xml;q=0.9,*/*;q=0.8 +-- ヘッダ Accept-Language ja,en-us;q=0.7,en;q=0.3 | Accept-Encoding gzip, deflate | Accept-Charset Shift_JIS,utf-8;q=0.7,*;q=0.7 | Keep-Alive 115 | Connection keep-alive | Referer http //example.jp/31/ --+ Accept-CharsetでShift-JISの品質係数が1であるため、サーバは、Shift-JISでエンコードしたメッセージを返す。 POST http //example.jp/31/31-003.php HTTP/1.1 リクエストライン Accept image/gif, image/jpeg, image/pjpeg, image/pjpeg, application/vnd.ms-excel ヘッダ Referer http //example.jp/31/31-002.php Accept-Language ja User-Agent Mozilla/4.0 (compatible; MSIE 8.0; Windows NT 5.1; Trident/4.0; .NET CLR 1.1.4322; .NET CLR 2.0.50727; Inf oPath.1; .NET CLR 3.0.4506.2152; .NET CLR 3.5.30729) Content-Type application/x-www-form-urlencoded Accept-Encoding gzip, deflate Host example.jp Content-Length 65 Connection Keep-Alive Pragma no-cache name=%E8%8F%85%E7%9B%B4%E4%BA%BA mail=kan@aaa.jp gender=%E7%94%B7 メッセージボディ Hostヘッダ HTTP1.1では必須。POST/GETでのURIにHOSTを指定していなかった場合、Virtualホストを特定できない。そのためHostヘッダにHOST名を指定する。URIにホスト名があって、Hostヘッダにもホスト名がある場合はURIを優先する。URIにホスト名を指定することを強制すれば良いような気がするが。 Referer ヘッダの一種。リンク元のURLを示す。あるWebページのリンクをクリックして別のページに移動したときの、リンク元のページのこと。 改変、削除される場合があるので正しくリンクを示しているとは限らない。 セキュリティ上、問題となるのは、URLが秘密情報を含んでいる場合。たとえば、URLがセッションIDを含んでいる場合。なりすましに使われる可能性がある。 【例】 GET http //example.jp/31/31-002.php HTTP/1.1 Accept image/gif, image/jpeg, image/pjpeg, image/pjpeg, application/vnd.ms-excel, application/vnd.ms-powerpoint, appl ication/msword, application/x-shockwave-flash, application/x-ms-application, application/x-ms-xbap, application/vnd.ms -xpsdocument, application/xaml+xml, */* Referer http //example.jp/31/ Accept-Language ja User-Agent Mozilla/4.0 (compatible; MSIE 8.0; Windows NT 5.1; Trident/4.0; .NET CLR 1.1.4322; .NET CLR 2.0.50727; Inf oPath.1; .NET CLR 3.0.4506.2152; .NET CLR 3.5.30729) Accept-Encoding gzip, deflate Host example.jp Connection Keep-Alive http //example.jp/31/のHTMLのaタグからリクエストが発生したため、Refererヘッダがつく。 レスポンス 全てテキスト。行で区切られる。 フォーマット ステータスラインは1行。ヘッダ、ボディは複数行。 大項目 小項目 説明 ステータスライン プロトコルバージョン ステータスコード 1XX 処理継続、2XX 正常終了、3XX リダイレクト、4XX クライアントエラー、5XX サーバエラー テキストフレーズ レスポンスヘッダ Content-Length ボディのバイト数 Content-Type MIMEタイプ; charset=エンコーディング 空行 ヘッダの終わりを示す ボディ 【例】 HTTP/1.1 200 OK Date Wed, 04 May 2011 04 51 51 GMT Server Apache/2.2.14 (Ubuntu) X-Powered-By PHP/5.3.2-1ubuntu4.2 Vary Accept-Encoding Content-Length 20 Keep-Alive timeout=15, max=100 Connection Keep-Alive Content-Type text/html; charset=UTF-8 body 13 51 /body Content-type メディアタイプを示すエンティティヘッダ(メッセージボディに対する付随情報)。type "/" subtype *( ";" parameter )であらわされる。text/html; charset=utf-8など。charsetを追加すると出力の文字コードを示す。HTML文書にapplication/octet-streamを付けると、 多くの場合、Webブラウザはそれをダウンロードするか否か問い合わせるようになる。 Apacheの場合は、httpd.confの以下の設定でcharsetを指定する。 AddDefaultCharset UTF-8 Tomcatでは、JSPのpageディレクティブで設定する。 %@ page language="java" contentType="text/html; charset=Windows-31J" pageEncoding="Windows-31J" % http //www.atmarkit.co.jp/fjava/rensai3/mojibake01/mojibake01.html 参照
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=物質情報= 【物質名】 Methylone:2-methylamino-1-(3,4-methylenedioxyphenyl)propan-1-one 【摂取量目安】 経口摂取 125-200mg (ErowidにDose記載無しの為、レポートより) 【持続時間目安】 経口 2 - 4時間 耐性や摂取量で大幅に前後する可能性があります。 【死亡事例の有無(分かる範囲で)】 【禁忌】 【参考リンク】 Erowid: ttp //www.erowid.org/chemicals/methylone/methylone.shtml ※摂取量や持続時間はあくまで目安です。体重・精神及び肉体的な向き不向きがあります。 酒類・他の薬との併用は重大な事故を起こす可能性があります。
https://w.atwiki.jp/artist-biography/
Ryota Matsumoto - Artist, Architect, Author Ryota Matsumoto (松本良多) is the Japanese philosopher and visual artist known for the postdigital theory and hybrid art. He is a principal and founder of an award-winning interdisciplinary design office, Ryota Matsumoto Studio based in New York and Tokyo. Education Born in Tokyo, he was raised in Hong Kong and Japan. He received a Master of Architecture degree from University of Pennsylvania in 2007 after his studies at Architectural Association in London, Mackintosh School of Architecture, Glasgow School of Art and University of Miami in early 90’s. Matsumoto has previously collaborated with a cofounder of the Metabolist Movement, Kisho Kurokawa, and with Arata Isozaki, Peter Christopherson, Cesar Pelli and MIT Media Lab before establishing his office. Biography As a designer and consultant of Nihon Seikei Inc. and Japanese railway, he has worked on high-profile projects including Kyushu University Ito Campus masterplan(2003-2005), Shinjuku redevelopment project in Tokyo(2009-2012), Bach Mai hospital in Hanoi(2000) and Qingdao mixed-use development in China(2011). He has presented his work on posthumanism, digital design and bio art at the 5th symposium of the Imaginaries of the Future at Cornell University, the Espaciocenter workshop at TEA Tenerife Espacio de las Artes, Oslo National Academy of the Arts, UCI Claire Trevor School of the Arts and NTT InterCommunication Center as a visual artist. As a video producer, he has worked with Peter Christopherson of Coil and Hipgnosis for Japanese Nike commercial and contributed to the promotional projects for his first solo album as Threshold Houseboys Choir. His academic career started as a teaching assistant for architectural historian, Vincent Joseph Scully Jr. and his seminar, the Natural and Manmade in 1993. During his visiting fellowship at the Glasgow school of Art, he has been engaged in research on the process of integrated urban regeneration under the guidance of Giancarlo De Carlo and Isi Metzstein. He continued his pursuit in urban studies and participated in seminal research projects with MIT Media Lab and KieranTimberlake exploring high-rise modular housing, sustainability and design interventions for Dhaka, Bangladesh in 2005. He has served as an MFA advisor of Transart institute, University of Plymouth and teaches at Asagaya Institute of Art and Design as a professor of practice. He is a research associate at the New Centre of Research Practice found by Mohammad Salemy, Jason Adams and Reza Negarestani. Awards Matsumoto is the recipient of Visual Art Open First Prize, FILE (Electronic Language International Festival) Prix Lux Prize, Florence Biennale Mixed Media 2nd Place Award, Premio Ora Prize Italy 5th Edition, Premio Ora Prize Spain 1st Edition, Donkey Art Prize III Edition Finalist, Best of Show IGOA Toronto, Art Kudos Best of Show Award, Lynx International Prize Be Art Builder Award, Lumen Prize Finalist and Western Bureau Art Prize Honorable Mention. He was awarded the Gold Artist Prize from ArtAscent Journal, the 1st Place Prize from Exhibeo Art Magazine and the Award of Excellence from the Creative Quarterly Journal of Art and Design in 2015 and 2016. His work is part of the permanent collection of University of Texas at Tyler. Writings His work, writings, and interviews were published in Kalubrt Magazine, University of North Carolina Wilmington Journal Palaver, Furtherfield.org, The Journal of Wild Culture, Studio Visit Magazine, Fresh Paint Magazine, H+ Magazine, International Artist Magazine, Made In Mind Magazine, Arizona State University Journal Superstition Review, Creative Review, Next Nature Network, Rhizome.org, Carbon Culture Review, KooZA/rch, Supersonic Art, Component Design (Winka Dubbeldam ed.), Post Digital Aethetics (Berry and Dieter ed.), Drawing Discourse (University of North Carolina Asheville), Highlike(SEPI-SP editors) and Drawing Futures (The Bartlett UCL) among others. Exhibitions Matsumoto s multidisciplinary projects have been exhibited recently at Meadows Gallery University of Texas at Tyler, S. Tucker Cooke Gallery University of North Carolina Asheville, Sebastopol Center for the Arts, National Museum of Korea, Van Der Plas Gallery, ArtHelix Gallery, Caelum Gallery, Limner Gallery, the Cello Factory, University of the District of Columbia, Lux Art Gallery, Studio Montclair, Manifest Gallery, Tenerife Espacio de las Artes, Art Basel Miami, ISEA International, FILE Sao Paulo, Nook Gllery and Arts and Heritage Centre Altrincham. He also had solo exhibitions at Transylvania University (2015), Los Angeles Center of Digital Art (2016) and Alviani ArtSpace, Pescara (2017). Links The Official Website https //www.ryotamatsumoto.com The Centre of Research Practice https //thenewcentre.org/people/ryota-matsumoto World Biographical Encyclopedia https //prabook.com/web/ryota.matsumoto/619708 Facebook https //www.facebook.com/ryota.matsumoto.718 Instagram https //www.instagram.com/ryt.matsumoto LinkedIn https //www.linkedin.com/in/ryota-matsumoto-68746080 Discogs https //www.discogs.com/ja/artist/5796857-Ryota-Matsumoto Muck Rack Journalist Profile https //muckrack.com/ryota-matsumoto References Ryota Matsumoto and Hybrid Architecture, Athanor Journal https //www.athanor.world/5/matsumoto_hybrid-architecture.html Interview with Ryota Matsumoto, Roadrunner Review, La Sierra University Press https //roadrunner.lasierra.edu/interview-with-ryota-matsumoto-artist The Alchemy of Oblique Strategy, Ryota Matsumoto, Interalia Magazine https //www.interaliamag.org/audiovisual/ryota-matsumoto
https://w.atwiki.jp/metalmetabo/pages/31.html
- visitors The small world inside large metabolic networks royalsocietypublishing.org [PDF]A Wagner, DA Fell - … of the Royal Society of London …, 2001 - rspb.royalsocietypublishing.org http //scholar.google.com/scholar?q=related RzgGd87o6owJ scholar.google.com/ hl=ja as_sdt=2000 Page 1. doi 10.1098/rspb.2001.1711 , 1803-1810 268 2001 Proc. R. Soc. Lond. B Andreas Wagner and David A. Fell The small world inside large metabolic networks References http //rspb.royalsocietypublishing.org/content/268/1478/1803#related-urls Article cited in ... In silico predictions of Escherichia coli metabolic capabilities are consistent with experimental data vcu.edu [PDF]JS Edwards, RU Ibarra, BO Palsson - Nature biotechnology, 2001 - nature.com http //scholar.google.com/scholar?q=related E0x6EPMqz7kJ scholar.google.com/ hl=ja as_sdt=2000 ... J. Theor. Biol. 203, 249–83 (2000). | Article | PubMed | ISI | ChemPort |; Schilling, CH, Schuster, S., Palsson, BO Heinrich, R. Metabolic pathway analysis basic concepts and scientific applications in the post-genomic era. Biotechnol. Prog. 15, 296–303 (1999). ... The small world of metabolism stanford.edu [PDF]DA Fell, A Wagner - Nature Biotechnology, 2000 - nature.com http //scholar.google.com/scholar?q=related vJDOQbOxaVoJ scholar.google.com/ hl=ja as_sdt=2000 ... propositions. Top of page References. Schilling, CH, Schuster, S., Palsson, BO Heinrich, R. Metabolic pathway analysis basic concepts and scientific applications in the post-genomic era. Biotechnol. Prog. 15, 296–303 (1999). ... Metabolic pathways in the post-genome era psu.edu [PDF]JA Papin, ND Price, SJ Wiback, DA Fell, BO … - Trends in Biochemical …, 2003 - Elsevier http //scholar.google.com/scholar?q=related yCUSHfucTk8J scholar.google.com/ hl=ja as_sdt=2000 ... All possible flux distributions of a metabolic network lie within the cone circumscribed by the pathways. View Within Article. 1. History of network-based metabolic pathway analyses. Network-based metabolic pathway analysis has a relatively short history. ... The Escherichia coli MG1655 in silico metabolic genotype its definition, characteristics, and capabilities pnas.org [HTML]JS Edwards, BO Palsson - … of Sciences of the United States …, 2000 - National Acad Sciences http //scholar.google.com/scholar?q=related ylmoiEQjy08J scholar.google.com/ hl=ja as_sdt=2000 ... These methods include approaches such as metabolic control analysis (3, 4), flux balance analysis (FBA) (5–7), metabolic pathway analysis (8–11, 69), cybernetic modeling (12), biochemical systems theory (13), temporal decomposition (14), and so on. ... Analysis of metabolic capabilities using singular value decomposition of extreme pathway matrices nih.gov [HTML]ND Price, JL Reed, JA Papin, I Famili, BO Palsson - Biophysical journal, 2003 - Elsevier http //scholar.google.com/scholar?q=related vBbGDsA7avcJ scholar.google.com/ hl=ja as_sdt=2000 Phylogenetic analysis based on genome-scale metabolic pathway reaction content silicobio.com [PDF]SH Hong, TY Kim, SY Lee - Applied microbiology and biotechnology, 2004 - Springer http //scholar.google.com/scholar?q=related 2MW2dxoUfOIJ scholar.google.com/ hl=ja as_sdt=2000 Page 1. Appl Microbiol Biotechnol (2004) 65 203–210 DOI 10.1007/s00253-004-1641-3 GENOMICS AND PROTEOMICS SH Hong . TY Kim . SY Lee Phylogenetic analysis based on genome-scale metabolic pathway reaction content ... Extreme pathway lengths and reaction participation in genome-scale metabolic networks cshlp.org [HTML]JA Papin, ND Price, BØ Palsson - Genome research, 2002 - genome.cshlp.org http //scholar.google.com/scholar?q=related o1ZwGAWEzSUJ scholar.google.com/ hl=ja as_sdt=2000 ... Schilling CH,; Schuster S.,; Palsson BO,; Heinrich R. (1999) Metabolic pathway analysis Basic concepts and scientific applications in the post-genomic era. Biotech. Prog. 15 296–303. ... Flux coupling analysis of genome-scale metabolic network reconstructions cshlp.org [HTML]AP Burgard, EV Nikolaev, CH Schilling, CD … - Genome …, 2004 - genome.cshlp.org http //scholar.google.com/scholar?q=related IXLhT3n9KwQJ scholar.google.com/ hl=ja as_sdt=2000 Metabolic modeling of microbial strains in silico ru.nl [PDF]MW Covert, CH Schilling, I Famili, JS Edwards, … - Trends in Biochemical …, 2001 - Elsevier http //scholar.google.com/scholar?q=related pjh6sWp3MRMJ scholar.google.com/ hl=ja as_sdt=2000 ... References. Schilling, CH et al., Metabolic pathway analysis basic concepts and scientific applications in the post-genomic era. Biotechnol. Prog. 15, pp. 296–303. Schilling, CH et al., Towards metabolic phenomics analysis of genomic data using flux balances. Biotechnol. ...
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- visitors In vivo analysis of intracellular amino acid labelings by GC/MS. C Wittmann, M Hans, E Heinzle - Analytical biochemistry, 2002 - mendeley.com ... TBDMS derivatization of amino acids is especially useful in metabolic network analysis, because M-57 fragments containing the entire carbon skeleton of the analyte can be observed by GC/MS with high signal intensities 8. The potential of the method is exemplified for ... Comparative metabolic flux analysis of lysine-producing Corynebacterium glutamicum cultured on glucose or fructose nih.gov [HTML]P Kiefer, E Heinzle, O Zelder, C … - Applied and …, 2004 - Am Soc Microbiol ... A comprehensive approach to 13 C tracer studies, labeling measurements by gas chromatography-mass spectrometry, metabolite balancing, and isotopomer modeling, was applied for comparative metabolic network analysis of lysine-producing Corynebacterium glutamicum ... It is all about metabolic fluxes nih.gov [HTML]J Nielsen - Journal of bacteriology, 2003 - Am Soc Microbiol http //scholar.google.com/scholar?q=related xAvLLrdbbNYJ scholar.google.com/ hl=ja as_sdt=2000 ... I. Experimental observations. Biotechnol. Bioeng. 55 305-316.[CrossRef] 21; Thykaer, J., B. Christensen, and J. Nielsen. 2002. Metabolic network analysis of an adipoyl-7-ADCA producing strain of Penicillium chrysogenum elucidation of adipate degradation.Metab. Eng. ... Using topology of the metabolic network to predict viability of mutant strains biomedcentral.com [PDF]Z Wunderlich, L Mirny - Genome Biology, 2005 - biomedcentral.com http //scholar.google.com/scholar?q=related sTavonuje7wJ scholar.google.com/ hl=ja as_sdt=2000 ... Ph.D. Thesis. University of Leeds; 1994. 14. Papp B, Pal C, Hurst LD Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast. Nature 2004, 429(6992) 661-664. 15. Jeong H, Tombor B, Albert R, Oltvai ZN, Barabasi AL The large-scale ... Novel proteins, putative membrane transporters, and an integrated metabolic network are revealed by quantitative proteomic analysis of Arabidopsis cell … plantphysiol.org [HTML]H Eubel, EH Meyer, NL Taylor, JD Bussell, N O … - Plant …, 2008 - Am Soc Plant Biol http //scholar.google.com/scholar?q=related aCgbR-dAtyMJ scholar.google.com/ hl=ja as_sdt=2000 ... This is aided by a metabolic network analysis that reveals a tight integration of functions and highlights specific metabolite nodes that most probably represent entry and exit metabolites that could require transport across the peroxisomal membrane. ... High-throughput phenomics experimental methods for mapping fluxomes bjmu.cn [PDF]U Sauer - Current opinion in Biotechnology, 2004 - Elsevier http //scholar.google.com/scholar?q=related XvhSxXXwbn4J scholar.google.com/ hl=ja as_sdt=2000 ... From its early days when material fluxes were balanced within assumed reaction networks [7.], metabolic network analysis [6. and 8.] has matured to actually identify the topology of active reactions and pathways and to quantify the molecular flux through them on a variety of ... Use of genome-scale microbial models for metabolic engineering KR Patil, M Åkesson, J Nielsen - Current opinion in biotechnology, 2004 - Elsevier http //scholar.google.com/scholar?q=related oAOz5SBTVHAJ scholar.google.com/ hl=ja as_sdt=2000 ... incorporate genome-scale biological data. Genome-scale stoichiometric models of microorganisms represent a first step in this direction. FBA, flux balance analysis; MFA, metabolic flux analysis; MNA, metabolic network analysis. ... Network identification and flux quantification in the central metabolism of Saccharomyces cerevisiae under different conditions of glucose repression nih.gov [HTML]AK Gombert, M Moreira dos Santos, B … - Journal of …, 2001 - Am Soc Microbiol http //scholar.google.com/scholar?q=related R5V_AodxCrwJ scholar.google.com/ hl=ja as_sdt=2000 ... flux estimates. The use of 13 C-labeled substrates enables both identification of the metabolic network structure and quantification of the metabolic fluxes and is therefore referred to as metabolic network analysis (5). This kind ... Metabolic flux analysis of Escherichia coli K12 grown on 13C-labeled acetate and glucose using GC-MS and powerful flux calculation method freelogy.org [PDF]J Zhao, K Shimizu - Journal of biotechnology, 2003 - Elsevier http //scholar.google.com/scholar?q=related w1m-5IKYKpsJ scholar.google.com/ hl=ja as_sdt=2000 Structural and functional analysis of cellular networks with CellNetAnalyzer biomedcentral.com [HTML]S Klamt, J Saez-Rodriguez, ED Gilles - BMC Systems Biology, 2007 - biomedcentral.com http //scholar.google.com/scholar?q=related bzwlVku0FL8J scholar.google.com/ hl=ja as_sdt=2000 ... CNA extends its predecessor FluxAnalyzer, originally developed for metabolic network analysis[7], by new methods for signalling and regulatory networks, ie for networks where signal flows are dominating (in contrast to mass flows in metabolic networks). ...
https://w.atwiki.jp/croquette/pages/56.html
Depression nishitarumizu 2000.9.1 Overview Lifetime risk 7% to 12% for men, 20% to 25% for women. As many as two-thirds of the people suffering from depression do not realize that they have a treatable illness and do not seek treatment. Clinical depression commonly occurs concurrently with other medical illnesses and worsens the prognosis for these illnesses. Tip-offs for depression in a primary care setting May include fatigue, somatic complaints (such as headache, backache, chest pain, dyspepsia, and limb pain), anxiety symptoms, depressed mood, or insomnia. Risk factors female (especially post partum), history of depressive illness in first-degree relatives, prior episodes of major depression, prior suicide attempts, age 40 years, medical comorbidity, decreased social support, stressful life events, and current substance or alcohol abuse. Symptoms can be divided into 1. Emotional. Dysphoria, irritability, anhedonia, withdrawal. 2. Cognitive. Self-criticism, sense of worthlessness or guilt, hopelessness, poor concentration, memory impairment, delusions or hallucinations. 3. Vegetative. Fatigue, decreased energy, insomnia, hypersomnia, anorexia, psychomotor retardation or agitation, impaired libido. Diagnosis Depression is often difficult to diagnose because it can manifest in many different forms. Depression is a holistic disorder, affecting body, feelings, thoughts and behaviors. In addition to Depressed mood or Anhedonia ( loss of interest or pleasure ), five or more of the following symptoms have been present during the same two week period ESCAP-GS E nergy decreased S leep disturbance (classically , early awakening ; or may sleep longer than usually) C oncentration disturbance A ppetite disturbance (increased or decreased; with or without weight loss) P sychomotor changes G uilt (self-deplication, feelings of worthlessness) S uicidal thinking Depressed mood is neither necessary nor sufficient for a diagnosis of depression. Barriers to diagnosis Patient Barriers Somatic Presentations Stigma Clinician barriers Pandora’s Box Normal feature At least 50% of depressed patients are either undetected or are not adequately treated by primary care providers. Evaluation History May use Beck Depression Scale , Zung Depression Scale, or Geriatric Depression Scale to screen for high-risk patients. If depressive symptoms are present, determine a. Time course and severity. b. Any prior episodes and level of recovery. c. Any history of manic or hypomanic episodes. d. If other major psychiatric disorders are present. e. Any suicidal ideation, plan, or intent. Examination Evaluate for possible related medical conditions anemia, hypothyroidism, chronic infection, substance abuse, or medication side effects (oral contraceptives,antihypertensives, etc.). Causes of organic depressions Type Specific Cause Drugs corticosteroids,contraceptives,reserpine, antibiotics alpha-methyldopa,anticholinestherase, cimetidine ranitidine, indomethacin, phenothiazines, thallium mercury, cyclosporine, vincristine, vinblastine Drug withdrawal amphetamine, cocaine Infection Tertiary syphillis, influenza, AIDS, viral pneumoniae Viral hepatitis, infectious mononucleosis, Tb Endocrine Hypothyroidism, apathetic hyperthyroidism, Hyperparathyroidism, postpartum and menses-related, Cushing’s disease, adrenal insufficiency Collagen SLE, RA, vasculitis Neurologic MS, Parkinson’s disease, head trauma Complex partial seizures, CNS tumors, stroke, Early dementia, sleep apnea Nutritional Vitamine deficiencies (B12, C, folate, niacin, thiamine) Neoplastic Pancreatic cancer, disseminated carccinomatosis Others Renal Failure,Liver Failure, Alcohol/Substance Abuse Lab tests Screen for medical causes of depression (if suspected by Hx or Pex) Complete blood count (CBC) Electrolytes, including calcium, phosphate, magnesium BUN and Creatinine Calcium Serum toxicology screen TSH level CT or MRI of brain Electrocardiogram (ECG), Electroencephalogram (EEG) Physical Psychomotor retardation or agitation, such as slowed speech, sighs, and long pauses Slowed body movements, even to the extent of motionlessness or catatonia Pacing, handwringing and pulling on hair Preoccupation Lack of eye contact Tearfulness Self-deprecatory manner Memory loss, poor concentration and poor abstract reasoning Consultations Psychiatry should be consulted after a screening evaluation is complete and all acute medical complications are addressed. Treatment Treatment is effective in at least 70% of cases. Communicating with depressed patients Empathy Presenting the diagnosis “These symptoms indicate to me that you are suffering from depression.” It can be helpful to then add a couple of additional symptoms not mentioned by the patient. It is helpful to explain depression as a common biological disorder. Drawing a picture of a synapse and neurotransmitters may be helpful. Depression is a curable illness. Counseling by the physician SPEAK approach Schedule Pleasurable activities Exercise Assertiveness Kind thoughts about onself Psychotherapy cognitive therapy behavioral therapy Medication Most antidepressants believed to be equally effective in equivalent therapeutic doses. Expect a 2- to 6- week latent period before the full effect is seen at therapeutic doses. To prevent relapse, continue medication for at least 4 to 9 months after patient becomes asymptomatic. For recurrent depression, consider chronic prophylactic therapy. If at 6 weeks a patient shows no response or a poor response to an adequate dose of antidepressant medication , treatment should be changed. Tricyclic antidepressants (TCAs). Choose between them based on patient s sedation requirements and ability to tolerate orthostatic hypotension, weight gain, and anticholinergic adverse effects TCAs are usually given QHS to take advantage of sedating effects. All TCAs may cause slowing of cardiac conduction. May be fatal in overdoses around 2000 mg or more in adults. A therapeutic trial usually is considered 100 mg/day of amitriptyline or its equivalent for at least 3 weeks. Note Nortriptyline (Pamelor) has a "therapeutic window" plasma level of 50 to 150 ng/ml for optimal efficacy. It has the lowest risk for orthostatic hypotension of all TCAs making it a safe choice in the geriatric patient. Selective serotonin reuptake inhibitors (SSRIs) Much safer in overdose than TCAs. Expensive in contrast to generic TCAs. Initial dose often an effective dose. May need to start at lower doses in the elderly of others sensitive to side effects. Side effects vary and may include nausea, anorexia, insomnia or mild sedation, sweating, headache, tremor, sexual dysfunction, and nervousness. Fluvoxamine is contraindicated with astemizole and terfenadine. All SSRIs contraindicated with MAOIs. If switching from a SSRI to a MAOI, need a drug-free period of 14 days for paroxetine, sertraline or fluvoxamine or 5 weeks for fluoxetine. Monoamine oxidase inhibitors (MAOIs) Sometimes used in depression refractory to the other treatments. Consider consulting psychiatrist before starting because of the serious adverse effect potential. St. John’s wort For short-term treatment of mild acute depression. Equally effective. Induction of the cytochrome P450 system. Psychostimulants Methylphenidate(Ritalin) They take effect very quickly( 24h) Provide a relatively quick test of whether antidepressants are likely to be effective. Electroconvulsive therapy. ECT is the most effective, rapid method of treating severe major depressive disorder (MDD). Indicated for patients with poor response to medications, poor tolerance of usual antidepressants, severe vegetative symptoms, or psychotic features. The decision to administer ECT should be made by a psychiatrist. Figure. Adverse effects of selective serotonin reuptake inhibitors (striped bars) and tricyclic antidepressants (white bars). REFERENCE Pharmacologic Treatment of Acute Major Depression and Dysthymia Ann Intern Med. 2000; 132 738-742 Behavioral Medicine in Primary Care A Practical Guide 1st.ed. Assessing and Managing Depression in the Terminally ill Patients. Ann Intern Med. 2000; 132 209-218 http //www.wellbutrin-sr.com/eval/zung.htm http //www.vh.org/Providers/ClinRef/FPHandbook/Chapter15/01-15.html#Box%2015-1 http //www.emedicine.com/emerg/index.shtml